![]() If you would like to show or recommend your completed chess game to your friends or to interested chess players, simply copy the link provided at the top next to the star. If a player is watching the game you are currently playing, he/she will appear as anonymous or as a user, displayed by the spectator logo. Play chess online for free on with over 100 million members from around the world. Earn points for games played, won and screenshots shared. Change how often pieces return to the game after being captured. Death is but a momentary thing for the chess pieces in Undead Chess. We will also save your game in the chess database and it can be viewed or analyzed at any time by you or by other players. Pieces rise from their graves in this hauntingly fun game of chess. White has won" and can then request a return match, or play another chess player (New Player). You can challenge a strong chess engine Stockfish. If the computer program beats you, or you put the computer program into checkmate with the white pieces, then you will see the message "Checkmate. Play chess against the computer engine, and grow your chess skill. When you set up your new game, you can also configure the time control, which means thinking time will also be limited.ĭuring the ongoing game, the status "It's your move" will usually appear because the computer calculates its moves very quickly, and performs these moves on the chessboard immediately after your move. To start the game, simply click on the Start button and start playing the chess computer. Start playing chess now against the computer at various levels, from easy level one all the way up to master level. Play chess against the computer from Level 1 to Master ![]()
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![]() ![]() If you are interested in this option, please contact our office. Download vector polygon background with irregular tessellation pattern - triangular geometric design in sapphire color - blue and yellow Stock Vector and. This type of sticker is a fantastic way to decorate glass surfaces from the inside. Regular tessellations are composed of congruent regular polygons (triangles, squares, hexagons), while irregular tessellations are composed of irregular. If the ordered size exceeds the maximum width, the print will consist of multiple evenly cut sheetsįor use on: smooth, even walls glass or plexiglass surfacesįrontStick option: This product is also offered in an alternative version with the adhesive on the printed side of the sticker. The final irregular tessellation simulates stained glass and the elongated curved tiles faithfully express the large-scale flow in highly textured areas. Maximum width of a single sticker panel: 133cm. ✓ Transparent decoration – white elements of the design are completely transparent among a lattice, a tessellation, and a grid Explain how terrain elevation can be represented by a regular tessellation and by an irregular tessellation.Please contact our customer service to learn more. Irregular tessellations are more complex than regular ones, but they are also more adaptive, which typically leads to a reduction in the amount of. We can also cut the sticker to shape for you. Irregular Tessellations are partitions of space into mutually distinct cells, but now the cells may vary in size and shape, allowing them to adapt to the spatial phenomena that they represent. It is recommended for use on windows, glass-panelled doors and furniture (closets, cupboard, tables) as well as smooth, unicolored walls. ![]() Example 7 Figure 9 shows an example of irregular tessellation, in which all the polygons are regular and congruent. ![]() Our stained glass stickers are printed on translucent foil, which creates a stained glass effect. Irregular tessellations are those that are formed by irregular polygons, or by regular polygons but that do not meet the criterion that a node is a vertex of at least three polygons. ![]() ![]() WebIt is free open-source application for decompiling Flash SWF files. JPEXS Free Flash Decompiler-免费开源 Flash 反编译工具 To submit new issue or issue editation, you should login first. This is the place where all feature requests and bug reports of JPEXS Free Flash Decompiler (FFDec) are handled. Extract resources, convert SWF to FLA, edit ActionScript, replace images, sounds, texts or fonts. Opensource flash SWF decompiler and editor.JPEXS Free Flash Decompiler - Issue tracker JPEXS Free Flash Decompiler 18.4.0 add to watchlist send us an update Free 4 screenshots: runs on: Windows 11 Windows 10 32/64 bit Windows 8 32/64 bit Windows 7 32/64 bit file size: 12.6 MB.JPEXS Free Flash Decompiler (Windows) - Download … JPEXSFreeFlashDecompilerIssue Tracker Issue tracker Donate Blog If you are looking for the decompiler itself, visit arroz integral hacendado paquete 1 kg #1536 How to import a font into an SWF - JPEXS Free Flash Decompiler WebOpensource flash SWF decompiler and editor. Webjindrapetrik / jpexs-decompiler Public Notifications Fork 585 Star 3.6k Code Pull requests Actions Wiki Security Insights Releases Tags 2 days ago github-actions nightly2518 … guilhermina guinle luiz eduardo guinle JPEXS Free Flash Decompiler2 is developed by JPEXS. It is free open-source application for decompiling Flash SWF files.Ī quick look at JPEXS Free Flash Decompiler - YouTube Many Git commands … NSIS 0.9 - JPEXS Free Flash Decompiler - GitHub Java 95.5 - JPEXS Free Flash Decompiler - GitHub tia do lula corina guilhermina da silva More than 100 million people use … Insights - JPEXS Free Flash Decompiler - GitHub Resources - JPEXS Free Flash Decompiler - GitHub Idea - JPEXS Free Flash Decompiler - GitHub A tag already exists with the provided branch name. Contribute to jindrapetrik/jpexs-decompiler … GitHub is where people build software. Contribute to jindrapetrik/jpexs-decompiler … JPEXS Free Flash Decompiler. ![]() Extract resources, convert SWF to FLA, edit ActionScript, replace images, sounds, texts and … JPEXS Free Flash Decompiler. ![]() WebJPEXS Free Flash Decompiler Open Source Flash SWF decompiler and editor. Jpexs Free Flash Decompiler will analyze and repairs broken or corrupt JPS files, which in turn, will restore the original state of the file. ![]() WebA great alternative to the above-mentioned programs is Jpexs Free Flash Decompiler, which provides a simple way for users to compile opens files, which is otherwise a complex program. JPEXS Free Flash Decompiler for Windows - FileHippo others installed from ZIP just delete FFDec directory/app JPEXS Free Flash … sandálias confortáveis ortopédicas Linux debian based uninstall deb package as you usually do - sudo dpkg -r ffdec should probably do the trick. go to startmenu and from the JPEXS Free Flash Decompiler group, click on Uninstall JPEXS Free Flash Decompiler icon and follow directions.BitComet 1.99 » Comment Rules & Etiquette - We … quinta da regaleira poço.Screenshot for JPEXS Free Flash Decompiler « Ventoy 1.0.91.Why the jpexs tool not working when decompile swf file?ĭownload JPEXS Free Flash Decompiler - MajorGeeks ![]() ![]() ![]() Tons of enemy types including huge prehistoric creatures. ago no moga pocket support : ( EepOppOrkAhAhh 10 yr. Various weapon types - Bows, Crossbows, Hammers, Swords, Axes Ravensword: Shadowlands gets updated with full controller support droidgamers 28 16 Gaming 16 comments Best Add a Comment EepOppOrkAhAhh 10 yr. Reflex and precision based combat with manual blocking and dodging its the follow-up to the original Raven sword game which was one of the first heavy 3d action RPGs on the iOS and android. ![]() Ravensword: Shadowlands is a new RPG(Role-Playing Game) adventure game for Android with great 3D. Original Soundtrack from composer Sean Beeson Download free apk file Ravensword: Shadowlands 3d RPG apk is a kind of Role Playing Game for Android Phones and Tablets, manufactured by Crescent Moon Games. Download Free Android and PC Apps:Android to Apple. Explore a vast and richly detailed world, gather powerful weapons, collect hundreds of items, increase your skills, and follow a deep storyline to solve the mysteries of the Kingdom of Tyreas.įirst Person and 3rd Person on the fly switching Download GameLoop from the official website, then run the exe file to install GameLoop. ![]() Explore a vast and richly detailed world, gather powerful weapons, collect hundreds of. Ravensword brings unprecedented visuals to the role playing and adventure. Ravensword brings unprecedented visuals to the RPG and adventure games Ravensword brings unprecedented visuals to the role playing and adventure. From the award winning studio that brought you the great RPG's Ravensword: The Fallen King ![]() ![]() ![]() Employing a concept of biological naturalism grounded in cognitive theory, Myers argues for a clear delineation between the aesthetics of play and the aesthetics of texts. Updike pronounced the word / ˈ r eɪ d uː k s/.Play Redux is an ambitious description and critical analysis of the aesthetic pleasures of video game play, drawing on early twentieth-century formalist theory and models of literature. He hates that word, you see it everywhere, and he doesn't know how to pronounce it. ![]() In Rabbit at Rest, Rabbit notices:Ī story.in the Sarasota paper a week or so ago, headlined Circus Redux. The book's popularity resulted in a rise in the use of the word "redux" in popular discourse. Other works of literature using the same word in the title include John Dryden's Astraea Redux (1662), "a poem on the happy restoration and return of His Sacred Majesty," and Anthony Trollope's Phineas Redux (1873). Redux means "brought back, restored" (from the Latin reducere – bring back). The Rabbit novels, for all their grittiness, constitute John Updike's surpassingly eloquent valentine to his country." In 2015, The Guardian ranked it number 88 in a list of the 100 Best Novels. Joyce Carol Oates has said of the Rabbit novels, "The being that most illuminates the Rabbit quartet is not finally Harry Angstrom himself but the world through which he moves in his slow downward slide, meticulously recorded by one of the most gifted American realists. In later years, eminent critics and authors alike have praised the book. It may even-will probably-change your life." Let me give you just one random example: Jill's mother-rich, ripe spoiled-feels, when she finds out what happened to her daughter, "a grieved anger seeking its ceiling, a flamingo in her voice seeking the space to flaunt its vivid wings." But enough-for God's sake, read the book. He moves now with the sureness, grace and precision of the born athlete. He has sacrificed none of his sensibility-simply translated it into gutsier, more natural but no less eloquent rhythms. A masterpiece." Anatole Broyard, writing for The New York Times, opined, "In Rabbit Redux, Updike's ear is perfect and he has finally put together in his prose all the things that were there only separately. Time said of the book and its author, "Updike owns a rare verbal genius, a gifted intelligence and a sense of tragedy made bearable by wit. The Angstroms warily settle back into family life as they face the dawn of the 1970s.Ĭontemporary reviews of the book were generally positive and often glowing. The near-death experience causes them to reevaluate their relationship and Janice returns to Harry. Though Harry is initially disturbed, the nihilistic Skeeter convinces him to forget about it Harry nonetheless worries about the effect it may have on Nelson.Ĭharlie suffers a heart attack while he and Janice are together, but she saves his life. The activities at Harry's house upset his middle-class, conservative neighbors, one of whom sets fire to the house in an attempt to put an end to the commune. ![]() Against the backdrop of the Summer of Love, Harry, Skeeter, and Jill do drugs, have sex, and debate religion, race relations, and other political issues of the 1960s while Nelson attempts to romance Jill. While Skeeter keeps Jill in sexual thrall to him with heroin, Harry and Nelson are both drawn to Jill for the different things she represents to them: lost innocence and sexual conquest for Harry, and first love and coming of age for Nelson. Seeking to fill the void left by Janice, Harry starts a commune, composed of himself Nelson Skeeter, a cynical, drug-dealing African-American Vietnam vet with messianic delusions and Jill, a wealthy, white, runaway teenager from Connecticut. When his wife leaves him for an eccentric Greek man named Charlie Stavros, Harry and his thirteen-year-old son Nelson are at a loss. Thirty-six, he feels that he is quickly approaching middle age and irrelevance, a fear he sees reflected in the economic decline of his hometown, Brewer, Pennsylvania. Rabbit Redux finds former high-school basketball star Harry "Rabbit" Angstrom working a dead-end job as a Linotype operator at the local printing plant. ![]() It is the second book in his "Rabbit" series, beginning with Rabbit, Run and followed by Rabbit Is Rich, Rabbit At Rest, published from 1960 to 1990, and the related 2001 novella, Rabbit Remembered. Rabbit Redux is a 1971 novel by John Updike. ![]() ![]() ![]() ![]() Source code is also included with this.Įxtractor/inserter for the character names in the “Guide” in Fire Emblem 12.įire Emblem: Shin Monshou no Nazo - Hikari to Kage no EiyuuĪ 1bpp graphics editor specifically tailored for font editing and creation. Also comes with Game Boy ROM checksum repair option. This has the ability to change both object palette and the sprites associated.ġ,2,3,4 bpp NES, SNES, GB, GBA, WSx, SMS, GG, Neo Geo Pocket. This program is heavily influenced by Quaraage’s work on dkc2. However, this one has an English tra….ġ,2,3,4 bpp NES, SNES, GB, WSC, SMS, Genesis, NeoGeo PC, PCE Most versions found online are the older one that wanted registration and without English support. Unfortunately there is no full instruction manual for it. The internal operation mode, of the tool i….Ĭrystal Tile 2 is a nice tool written by a Chinese team. Written entirely in the Java programming language, this tool aims, using an image containing characters (source image) to generate an image with text written using existing characters in the image source. But it can be used on all kinds files to manipulate bits in a graphical way. I wrote this windows utility to view and hack graphics in Atari VCS2600 Roms. Map Editor – Change sector properties like palette and tilesets, as well as the map itself.This tool is for use with EBB/Z NES map and chunk editing. This game can hack any Atari 2600 game that it’s configured for. The “Big” font is Antonio Bold and “Small” is Sans.Ītari Hacking for Dummies Tool, with AHD Files. This editor supports over 200+….Ī graphics editor used to translate most of the text in Ace Combat 3: Electrosphere. There is support for editing text strings, maps, and attributes of some games as well. The source code is available for this graphic ….ĪGE allows the graphics inside certain arcade games to be edited, allowing you to modify or add completely new graphics to the game. This is how the acclaimed cRPG series started, created by the legend of computer gaming - Richard Garriott a.k.a.8TED is another graphic tile editor that supports many different formats such as.Find out for yourself how these retro graphics have caused so many sleepless nights Three epic adventures set in a vast, open world full of mysterious places, evil creatures, and deadly secrets.This pack includes: Ultima I, Ultima II: Revenge of the Enchantress and Ultima III: Exodus.This time a party of adventurers must act, their only clue a single word scrawled in blood upon the deck of a derelict merchant ship: EXODUS. The Great Earth Serpent stirs in its slumber of countless ages. Of the fruits of that alliance, none can speak, but soon the Orc drums boom again. In her fury, she has torn the fabric of time and space, opening doors through which you may bring about her doom!įinally, after years of peace, fragments of a manuscript hint at an unholy alliance between Mondain and Minax. Minax, apprentice of Mondain, has come of age, raining terror and destruction on the land. In your second quest, you will discover that, although the master is dead, his evil legacy lives on. Take up the weapons of time and sorcery in a battle to destroy Mondain. In the beginning of this adventure, hordes of nightmarish creatures stalk forth from the lair of Mondain the Wizard to devastate the tranquil kingdoms of Sosaria. ![]() ![]() ![]() The above examples highlight internal evidence because they have to do with that particular copy. When conducting textual criticism, you would consider the internal evidence and external evidence. This could show up in a copy that reads, “the fox jumped over the dog.” It’s still true and still captures the message, but it’s missing a few words. Even diligent scribes would make the occasional mistake. ![]() Perhaps the scribe was hungry or tired or lost their place while copying the original text. In this case, we can see that textual critics give more weight to the harder or clunkier reading, because it’s likely that a change in the text would make it easier to read.įinally, a copy would sometimes have an honest mistake. ![]() But the original line calls the fox “brown.” So it’s easy to see why this copy changes the text, because most changes are going to add clarity and make more sense. Meanwhile, another scribe wrote, “The red fox jumped over the lazy dog.” This makes sense, because foxes are usually red, not brown. Thankfully, the other copies retain the original line, so we would be able to know this scribe made some changes. Sometimes, scribes would make a change to the text to “improve” it or add their clarifying interpretations. But he changed the original text in the process. Now, imagine a scribe who’s making a new copy and writes, “The quick brown fox jumps over the lazy dog.” He feels better about himself because he knows this is intended as a sentence that uses every letter of the English alphabet, so the scribe completes the incomplete line. A Helpful ExampleĬonsider the following example that can help us understand how textual criticism works. The video at the bottom of this post is also a helpful discussion starter. Since this is a rather technical field of study, the following is a simplified way I have taught about it to teenagers. But it does mean they reject Scripture and Christianity for other reasons than the reliability of the Bible. This doesn’t mean every textual critic believes in the inspiration and authority of Scripture. Contrary to the popular objection, the Bible is a remarkably trustworthy ancient document. Textual Criticism is an approach that helps scholars identify the original text of an ancient document, using both external and internal evidence. A surprising source of help comes from a field of study called Textual Criticism. But students can read the Bible with confidence. It’s totally unreliable.” If the middle of this objection was true, then their conclusion would be too. It was made up by people way after the time of Jesus. It’s not uncommon to hear people say, “You can’t trust the Bible. ![]() ![]() The sequence that shows how far they've fallen from part two is the whole emo/hair in the eyes/eyeliner/oh so cool "bad" Spiderman scenes. From the first 15 minutes of Spiderman 3, I knew that all these parallel story lines were going to crash within the next two hours. There it was! Beautifully filmed and written. You had the inner struggle, the villain and his relationship with MJ. The great thing about Spiderman 2 (the best of the trilogy) is how focused it was. It was just WAY TOO MUCH! Even if you had four hours, it's just too much to cram into the audience in one sitting. Speaking of the writing, I hate to be beating a dead horse, but c'mon: 3 villains, Sandman's background, trouble with MJ, Harry's changing attitudes, 2 different Spidermans, competition at the Bugle, Gwen Stacy, etc. It was not in the way the writers intended it. Along with most other people I've talked to, my entire theater erupted in laughter when he started crying. Then came the horrific bridge scene with MJ. He just could not pull off the black suit he wasn't good at being bad. Maguire is a one note actor, at least as far as Spidey goes. I've always thought he was so great at Spidey, which is undeniable in the first two films and even in this one.when he has his red suit on. However, Tobey Maguire REALLY disappointed me. James Franco and Kirsten Dunst played their usual selves (I can't help but think of Dunst dreaming of getting back to work with Sofia Coppola while doing these films). I remember how outraged everyone was when he was chosen, but obviously someone knew what they were doing when they let him on as Venom. As far as acting goes, I'm surprised to say that Topher Grace stole the show. I thought these features would outbalance the weaker spots of the film, but unfortunately they did not. Spiderman's one-on-one fight with the Sandman and the crane scene being the major highlights. Raimi knows his material and embraces it. It's not like the recent Batman and Superman who try to hide the fact that they're just fun superhero films. He knows when to do what and realizes that he is making a superhero movie, which is why the Spider-man movies have done so well. It's plain to see that Sam Raimi is a fantastic director. "You liked it! C'mon! It's Spiderman!" Now, it's two days later, the euphoria of waiting for Spidey to come out has subsided, and I've begun to look at this flick a bit more (shall I say it?) critically. On the way home, I kept thinking to myself. My friends tensely asked if I liked it, I said "Yes, of course!!" They nodded weakly in response. The story follows the adventures of Miles Morales, a young Afro-Latino, who gets bitten by a radioactive spider while living in Brooklyn.As I was walking down the stairs and out of the theater, I was trying as hard as I could to pull a smile out of my face. Morales then teams up with Spideys from different worlds and alternate dimensions, including those from the Marvel comic books. The film has become an instant box office hit and has already won numerous awards.įans of Spider-Man will appreciate the unique biracial character, Miles Morales, in Into the Spider-Verse. Miles Morales is presented in a way that has never been achieved in any other Marvel superhero movie. ![]() ![]() It is no slight to Bendis, the writer of the comics, but Miles Morales’s character is better rounded in this new film than in any other.Īlthough Spider-Man 2099 isn’t given much screen time, he still makes an impression in Into the Spider-Verse. This new Spider-Man, voiced by Oscar Isaac, has a scary costume and is a fun riff on the original character. The villain of the film is known as the Kingpin, a powerful criminal in the Marvel universe. Liev Schreiber’s twisted character is the main antagonist of the movie. The Kingpin is played by Liev Schreiber, who also played the villain in Netflix’s Daredevil. The Amazing Spider-Man is a superhero who possesses special powers that allow him to fly and fight crime. Unlike many other superheroes, Spider-Man is a normal person who hides behind a mask. He was born to a scientist father and a photojournalist mother. His father was a scientist who studied genetic transplants. Peter Parker is now a college student, but he is unpopular with females and is constantly ridiculed by his classmates. ![]() The movie is about a superhero who fights against the sinister Six and a large network of villains. It is based on the comic book series “Spider-Man”. It is the third installment in the Spider-Man series. ![]() While it has some similarities with the first film, there are some significant differences between the films. The first film, released in 2007, had a different storyline and was aimed at a younger audience. In the new movie, Andrew Garfield reprises his role as the web-slinging hero, Spider-Man. The cast includes Emma Stone, Jamie Foxx, and Dan DeHaan. ![]() ![]() ![]() ![]() It was less than 200 years ago that people first figured out that the buzz they got from coffee and tea was the same buzz, produced by the same chemical agent. There's a joke in many cities that Starbucks is going to open a new store in the parking lot of the local Starbucks, but this is not true. Every working day, Starbucks opens four new outlets somewhere on the planet and hires 200 new employees. Meanwhile new coffee shops are opening so fast all over the world that even the most dedicated devotee of the triple-shot, no-foam, double-caramel, skinny macchiato can't keep track. Sales of Red Bull and copycat energy drinks with names like Red Devil, Roaring Lion, RockStar, SoBe Adrenaline Rush, Go Fast, and Whoop Ass are booming. In fact, most babies in the developed world enter the universe with traces of caffeine in their bodies, a transfer through the umbilical cord from the mother's latte or Snapple.Ĭaffeine's pervasiveness is a cause for concern among some scientists and public health advocates, but that hasn't dampened its popularity. It is the only habit-forming psychoactive drug we routinely serve to our children (in all those sodas and chocolate bars). The drug is encountered not just at the soda fountain or the espresso bar but also in diet pills and pain relievers. The dual power to counter physical fatigue and increase alertness is part of the reason caffeine ranks as the world's most popular mood-altering drug, eclipsing the likes of nicotine and alcohol. Really all they've found is a new kind of caffeine delivery system." They get you out of an energy slump and make you more alert. "But we've known for centuries that caffeinated drinks work. "The kids in the clubs, they think they've happened upon this great new invention," says Neil Stanley, director of sleep research at the Human Psychopharmacology Research Unit at Britain's University of Surrey. One 8.3-ounce (0.25-liter) can has two to three times the amount of caffeine as a 12-ounce (0.35-liter) can of soda. The active ingredient in the hugely successful Austrian product Red Bull is a solid jolt of caffeine, blended with a handful of other ingredients. I drink these two tins, it's like drinking a pint of speed."įor Lee Murphy and other habitués of the all-night club scene around the world-not to mention a legion of marathon runners, mountain bikers, fighter pilots, college crammers, and late-night truckers hoping to cover another hundred miles (160 kilometers) before turning in-the canned concoctions marketed as energy drinks represent a fizzy new manifestation of one of mankind's oldest stimulants: caffeine. "By four or five in the morning you're totally blotto," the 29-year-old London nurse explains. "It's like putting your whole system on fast-forward," Lee Murphy shouts above the din as he glides across the floor with four-inch-high (10-centimeter-high) soles on his dancing shoes, a gold ring in his chin, and a slender silver and blue can of Red Bull energy drink in each hand. At seven in the morning we have trouble getting them out the door." And the kids say, 'I've had eight Red Bulls-I'm flying!' They'll dance right round the clock. "That's when we get the real rush at the bar for Red Bull. "Actually, we usually see a revival about half four or so in the morning," says Egg night manager Simon Patrick. But after a long night of liquor, drugs, tobacco, and earthshaking noise, most are still vigorously, and happily, strutting their stuff across that trembling wood floor. at the popular London club Egg, and a few dancers have collapsed on the sofas or taken refuge at the bar. Through a purple haze of smoke and sweat the strobe lights' red glare illuminates the dancing couples: men with mohawks and painted faces, women in vinyl skirts so micro they serve no functional purpose. Over and over, the throbbing chorus of a dance hit explodes out of a battery of seven-foot-tall (2.1-meter-tall) speakers so powerful that the wood dance floor trembles, earthquake style, with every reverberating bass note. "Power! Money! Lust! Sex!" "Power! Money! Lust! Sex!" ![]() ![]() ![]() One Ab − patient had high levels of nonspecific binding in the insulin radioimmunoassay, and her insulin data were not included in this analysis. Insulin, C-peptide, glucagon, leptin, and adiponectin were measured using radioimmunoassay as before ( 9). ![]() Plasma glucose was measured with a glucose analyzer (Yellow Springs Instrument, Yellow Springs, OH). ![]() Subcutaneous abdominal adipose tissue (cm 2) All studies were approved by the University of Pittsburgh Institutional Review Board, and consents and assents were obtained prior to the investigation. None of the obese control subjects were on medications that affect blood glucose metabolism. The treatment modalities at the time of the study and the characteristics of the study population are summarized in Table 1. The control group consisted of 21 age-matched obese, otherwise healthy, adolescents recruited from the community. Islet cell antibodies were tested using the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-sponsored harmonization assay. Islet cell antibody screening revealed 25 with negative antibodies and 11 with positive antibodies. Thirty-six obese adolescents, all reported previously ( 8), with CDx-type 2 diabetes diagnosis made by the attending endocrinologist based on the American Diabetes Association diagnostic criteria ( 1), were recruited from the Diabetes Center at the Children's Hospital of Pittsburgh. Therefore, in this study, we investigated whether the oral glucose tolerance test (OGTT), a clinically applicable tool, could be used to distinguish the differences in insulin sensitivity and secretion between the two groups of patients with phenotypic type 2 diabetes versus obese control subjects with normal glucose tolerance. While the clamp technique is considered the gold standard for studying in vivo insulin secretion and sensitivity, its use is limited to the research setting. These pathophysiological differences have important bearing on the management of diabetes and highlight the importance of making the correct diagnosis. Moreover, the Ab − CDx-type 2 diabetic patients had features consistent with the metabolic syndrome. While insulin sensitivity was severely impaired in Ab − but not Ab + patients, β-cell function was almost completely abolished in Ab + and not Ab − type 2 diabetes ( 8). ![]() In a previous study using the hyperinsulinemic-euglycemic and the hyperglycemic clamp, we demonstrated important distinguishing features in insulin sensitivity and secretion between antibody-positive (Ab +) versus -negative (Ab −) obese youth with a clinical diagnosis of type 2 diabetes (CDx-type 2 diabetes). Moreover, 10–75% of physician-diagnosed obese youth with type 2 diabetes have islet cell autoantibodies ( 3, 5, – 7), which is the hallmark of autoimmune type 1 diabetes. However, the increasing prevalence of obesity in children, including those newly diagnosed with type 1 diabetes, has made the clinical distinction between the two types of diabetes more difficult ( 4). The diagnosis of type 1 versus type 2 diabetes in children relies largely on the clinical presentation with obesity being a major characteristic of children diagnosed with type 2 diabetes ( 1, 2). While type 1 diabetes remains the most common form of childhood diabetes, type 2 diabetes in youth has increased worldwide over the last decade concomitant with the epidemic increase in childhood obesity ( 2, 3). Diabetes in youth is generally classified into two major categories: type 1 diabetes characterized by autoimmune destruction of the pancreatic β-cells and absolute insulin deficiency and type 2 diabetes characterized by insulin resistance coupled with a nonimmune-mediated β-cell failure and relative insulin deficiency ( 1). ![]() |